In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63131-30-6, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 63131-30-6
General procedure: A mixture of 1H-benzo[d]imidazol-2-amine (1.5 mmol), ethyl 3-oxo-3-phenylpropanoate (0.5 mmol) and CBr4 (1 mmol) in CH3CN (2 mmol) was stirred in 80 C in a tube under air atmosphere. TLCmonitored the end of the reaction. Then the mixture was cooled toroom temperature and saturated brine (100 mL) was poured intothe solution. The mixture was extracted with EtOAc (3 50 mL).The organic phase was combined and dried by anhydrous Na2SO4.Finally, the product was separated by flash chromatography onsilica gel (petroleum ether/EtOAc 3: 1) and obtained aftervacuum-rotary evaporation.
The synthetic route of 63131-30-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Songhua; Li, Yunyi; Ma, Chen; Xie, Caixia; Tetrahedron; vol. 76; 9; (2020);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com