Electric Literature of 74-88-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 74-88-4 as follows.
General procedure: Iodomethane (1.606mmol) was added to a stirred solution of 1a (0.143mmol) and anhydrous potassium carbonate (0.352mmol) in dry CH2Cl2(2 mL), in an N2atmosphere at 55 C. The mixture was stirred for 24h and iodomethane (1.606mmol) was added once again and stirred for another 24h. After 48h, the reaction mixture was diluted in water (50 mL) and the aqueous phase was extracted with dichloromethane (3 x 50 mL). The resulting organic phase was washed with brine, dried over Na2SO4, filtered and evaporated. In order to produce a white solid, the organic phase was purified by silica gel chromatography using a gradient elution of C6H12/CH2Cl2(Yield: 24%).
According to the analysis of related databases, 74-88-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Cargnin, Simone Tasca; Staudt, Andressa Finkler; Medeiros, Patricia; de Medeiros Sol Sol, Daniel; de Azevedo dos Santos, Ana Paula; Zanchi, Fernando Berton; Gosmann, Grace; Puyet, Antonio; Garcia Teles, Carolina Bioni; Gnoatto, Simone Baggio; Bioorganic and Medicinal Chemistry Letters; vol. 28; 3; (2018); p. 265 – 272;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com