Electric Literature of 618-91-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 618-91-7, name is Methyl 3-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows.
3(ii) 3-Trimethylstannyl-benzoic acid methyl ester (3)Microwave 2 3To a mixture of methyl 3-iodobenzoate 200 mg, 0.76 mmol), and hexamethylditin (643 mul, 3.1 mmol) in toluene (8 ml) was added tetrakis (triphenylphosphine) palladium (0) (180 mg, 0.155 mmol (10 mol %). The reaction tube was flushed with argon, capped and heated in a microwave at 120C for 15 minutes. After cooling, TLC (ethyl acetate/hexane, 1 :1 ) showed complete conversion to product. Then the black suspension was filtered (filter paper) and the resulting dark coloured solution was evaporated to dryness. The residue was dissolved in ethyl acetate (15 ml) and extracted with water (6×10 ml).Then the organic phase was dried (MgSO4) filtered and evaporated under reduced pressure to afford the crude product as a dark oil (463 mg) which was purified by flash chromatography (Ethyl acetate: hexane, 1 :1 ) to afford a slightly yellow oil. Yield: 344 mg (74%).NB: Microwave irradiation was carried out in a Personal Chemistry Emrys synthesizer.1H NMR (500 MHz, CDCI3, £0.32 (s, 9H, Sn(CH3)3, 3.95(s, 3H, CH3), 7.40 (t, 1 H), 7.69 (d, 1 H), 8.0 (d 1 H), 8.20 (s, 1 H)
The chemical industry reduces the impact on the environment during synthesis Methyl 3-iodobenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GE HEALTHCARE LIMITED; AVORY, Michelle; BROWN, Jane; IVESON, Peter Brian; WO2010/86398; (2010); A1;,
Iodide – Wikipedia,
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