Application of 98-61-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 98-61-3, name is 4-Iodobenzenesulfonyl chloride belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 4-iodobenzenesulfonyl chloride 1 (500 mg, 1 66 mmol) in anhydrous acetomtrile (8 mL) under a nitrogen atmosphere was added pyrrolidine 2 (140 mg, 1 97 mmol) and pyridine (261 mg, 3 3 mmol) The reaction mixture was stirred at room temperature for 3 hours Ethyl acetate (100 mL) was added and the organic layer was washed with 1 N hydrochloric acid, water and brine The organic layer was dried over anhydrous sodium sulfate The organic solvent was evaporated under reduced pressure The crude product was purified by flash column chromatography to afford the desired l-[(4-iodobenzene)sulfonyl]pyrrohdme compound 78-1 (487 mg, 1 45 mmol)
The synthetic route of 4-Iodobenzenesulfonyl chloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MOCHIDA PHARMACEUTICAL CO., LTD.; SCHERING CORPORATION; NISHIDA, Hidemitsu; SAITOH, Fumihiko; HIRABAYASHI, Tomokazu; CHACKALAMANNIL, Samuel; CHAN, Tin-Yau; CHELLIAH, Mariappan, V.; CLASBY, Martin, C.; DWYER, Michael, P.; GREENLEE, William, J.; XIA, Yan; WO2010/65717; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com