Application of 58755-70-7, A common heterocyclic compound, 58755-70-7, name is 1-Iodo-4-methoxy-2-nitrobenzene, molecular formula is C7H6INO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a degassed solution of 2-(6-trimethylsilyl-3(Z)-hexen-1,5-diynyl)-1,2,3-trimethoxybenzene (15) (12 mmol) containing CuI (3.2 mmol) and K2CO3 (30 mmol) in MeOH (15 ml) was added a degassed solution of aryl iodides (16a-i) (12 mmol) containing Pd(PPh3)4 (0.8 mmol) in MeOH (20 ml). The resulting reaction mixture was stirred at room temperature for 4 h. The solvent was then removed in vacuo. The residue was quenched with saturated aqueous NH4Cl and extracted with EtOAc (20 × 3 ml). The combined organic extracts were washed with saturated aqueous Na2CO3 (40 ml) and dried over anhydrous MgSO4. After filtration and removal of the solvent in vacuo, the residue was purified by column chromatography on a silica gel to produce the desired products
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Lo, Yu-Hsiang; Lin, Ying-Ting; Liu, Yu-Peng; Duh, Tsai-Hui; Lu, Pei-Jung; Wu, Ming-Jung; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 526 – 533;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com