Adding a certain compound to certain chemical reactions, such as: 19821-80-8, name is 1,3-Dibromo-2-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19821-80-8, category: iodides-buliding-blocks
EXAMPLE 1; Preparation of 5-Bromo-9-isopropylidene-benzonorbornadiene (Compound No. 5.12); a) ยป-ButvUithium variant, from l,3-dibromo-2-iodo-benzene; To a stirred solution of l,3-dibromo-2-iodo-benzene (5.0Og, 13.8 mmol) and 6,6- dimethylfulvene (7.57g, assay 97%, 69 mmol) in dry toluene (60 ml) under a nitrogen atmosphere 5.5 ml of a 2.5M toluene solution of n-butyllithium (14.5 mmol) were added dropwise at O0C within 10 minutes. After a further 10 minutes at O0C and 1 hour at ambient temperature, the reaction mixture was poured onto a saturated aqueous solution of ammonium chloride, extracted with ethyl acetate, washed with brine and water, dried over sodium sulphate and evaporated. Purification of the crude material on silca gel in hexane afforded 2.55g of the desired product as a yellow oil (assay 99% by g.l.c, 70% yield). Yellow crystals of m.p. 90-910C were obtained from cold hexane.
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Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2007/68417; (2007); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com