Synthetic Route of 622-50-4, The chemical industry reduces the impact on the environment during synthesis 622-50-4, name is N-(4-Iodophenyl)acetamide, I believe this compound will play a more active role in future production and life.
[Rh(cod)(MeCN)2]BF4 (11.0 mg, 0.0300 mmol, 0.0300 equiv) and 4-iodoacetanilide (260 mg, 1.00 mmol, 1.00 equiv) were charged in 10 mL vial capped with a rubber septum. The vial was evacuated and backfilled with nitrogen. To this vial, DMF (4 mL), triethylamine (0.420 mL, 3.00 mmol, 3.00 equiv) and triethoxysilane (0.360 mL, 2.00 mmol, 2.00 equiv) were added. The reaction mixture was stirred at 80 C for 2 h, then cooled to 23 C. The mixture was diluted with ether (50 mL) and washed three times with water (3×20 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by Kugelrohr distillation to give 238 mg of the title compound as a colorless oil (80% yield). Rf=0.25 (hexanes/EtOAc 1:1 (v/v)). NMR spectroscopy: 1H NMR (500 MHz, CDCl3, 23 C, delta): 7.69 (d, J=8.0 Hz, 2H), 7.59 (d, J=8.5 Hz, 2H), 7.42 (br s, 1H), 3.85 (q, J=7.0 Hz, 6H), 2.17 (s, 3H), 1.23 (t, J=7.0 Hz, 9H). 13C NMR (125 MHz, CDCl3, 23 C, delta): 168.4, 139.8, 135.8, 126.3, 118.9, 58.7, 24.7, 18.2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(4-Iodophenyl)acetamide, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Tang, Pingping; Ritter, Tobias; Tetrahedron; vol. 67; 24; (2011); p. 4449 – 4454;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com