Application of 3718-88-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3718-88-5 name is 3-Iodobenzylamine hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Recrystallization from H2 O-EtOH provided m-iodobenzylguanidine sulfate as colorless crystals: mp 166-167 C.; HPLC [THF/0.1M NaH2 PO4 12/88, 3.0 ml/min] showed only one peak tR= 8.6 min; IR (nujol) 3340 (NH), 3160 (NH), 1660 and 1630 (C=N), 1090 (S=0), 780 and 695 cm (1,3-disubstituted benzene); PMR (CD3 OD) delta4.36 (S,2,CH2), 6.96-7.73 [m(7 peaks), 4,arom]; the aromatic peak pattern was identical to that observed for m-iodobenzylamine hydrochloride in CD3 OD. Anal. Calcd for C8 H10 IN3.O.5H2 SO4: C,29.64; H, 3.42. Found C,29.55,H, 3.40.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Iodobenzylamine hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; Wieland; Donald M.; Brown; Lawrence E.; Beierwaltes; William H.; Wu; Jiann-long; US4584187; (1986); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com