Reference of 628-77-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 628-77-3, name is 1,5-Diiodopentane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
1 ,5-diiodopentane (1 .54 mL, 3.35 g, 10.4 mmol) was added to a stirred solution of the phenol 12 (8.74 g, 20.7 mmol), TBAI (750 mg, 2.05 mmol) and K2003 (3.15 g, 22.8 mmol) in dry DMF (60 mL). The reaction mixture was heated to 70 00 and stirred under an argon atmosphere for 16 hours at which point analysis by LC/MS revealed substantial productformation at retention time 2.21 minutes, ES+ mlz 935 [M+ Na], 913 [M+ H]. The reaction mixture was allowed to cool to room temperature and the DMF was removed by evaporation in vacuo. The resulting residue was red issolved in EtOAc (200 mL) and the aqueous phase was washed with water (3 x 40 mL), brine (50 mL), dried (MgSO4), filtered and evaporated in vacuo to provide the crude product. Purification by lsoleraTM(Hexane/EtOAc, SNAP Ultra 100 g, 100 mL per minute) gave the bis-ether 13 (eluting at60% Hexane/EtOAc) as a yellow foam (6.75 g, 71% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Diiodopentane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MEDIMMUNE LIMITED; HOWARD, Philip Wilson; GREGSON, Stephen John; (228 pag.)WO2018/69490; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com