Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25309-64-2, name is 1-Ethyl-4-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 25309-64-2
13.20 g (31.64 mmol) of 1-benzyl-4-(benzyloxy)-3-iodopyridin-2(1H)-one are, together with 26.4 ml of triethylamine, initially charged in 224 ml of acetonitrile. 1.11 g (1.58 mmol) of bis(triphenylphosphine)palladium(II) chloride, 301 mg (1.58 mmol) of copper(I) iodide and 4.20 g (41.13 mmol) of ethynylbenzene are added, and the mixture is, under argon and with stirring, heated at 60 C. for 22 h. The mixture is then allowed to cool to room temperature, 11.01 g (47.45 mmol) of 4-ethyliodobenzene are added and the mixture is once more, under argon and with stirring, heated at 60 C. for 24 h. The mixture is then concentrated and filtered through silica gel (mobile phase: cyclohexane/ethyl acetate 1:1, then dichloromethane/methanol 95:5). The product-containing fractions are combined and concentrated. The product obtained in this manner is once more purified by column chromatography on silica gel (mobile phase: dichloromethane/methanol 100:3). The product-containing fractions are once more combined and concentrated. The residue is dissolved in warm ethyl acetate, a little activated carbon is added, the mixture is briefly heated to the boil and the activated carbon is filtered off again. After cooling to room temperature, the precipitated crystals are filtered off with suction, and more crystals are obtained from the mother liquor. In this manner, a total of 6.00 g (44.1% of theory) of the target compound are obtained.LC-MS (method 1): Rt=2.86 min; m/z=406 (M+H)+ 1H-NMR (400 MHz, CDCl3): delta=7.85 (d, 1H), 7.49-7.23 (m, 11H), 7.22 (d, 2H), 6.05 (d, 1H), 5.45 (s, 2H), 2.69-2.61 (q, 2H), 1.26-1.21 (t, 3H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25309-64-2.
Reference:
Patent; Lampe, Thomas; Kast, Raimund; Beck, Hartmut; Stoll, Friederike; Becker, Eva-Maria; Jeske, Mario; Schuhmacher, Joachim; US2010/261736; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com