Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16355-92-3, name is 1,10-Diiododecane, A new synthetic method of this compound is introduced below., SDS of cas: 16355-92-3
Example 5 Preparation of 4,4′-(1,12-dodecanediyl)bispyridine LDA (2M) (20 mL, 40.00 mmol) was added dropwise to a solution of 4-picoline (3.73 g, 40.00 mmol) in THF (60 mL) at -78 C. The mixture was stirred for 30 min and then 1,10-diiododecane (6.31 g, 16.00 mmol) in THF (10 mL) was added dropwise. The resulting mixture was warmed to room temperature and stirred for 4 hrs. 50% saturated NH4Cl was added to the reaction mixture. The aqueous phase was extracted with ethylacetate (40 mL*2), and the combined organic liquors were washed with 50% saturated brine (40 mL*3) and saturated brine (40 mL), dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product was purified by column chromatography (hexanes:ethylacetate 1:1 to 1:2) to afford 4.16 g of the title compound. Yield: 80%. 1H NMR (300 MHz, CDCl3) delta 1.18-1.40 (m, 16H), 1.53-1.70 (m, 4H), 2.59 (t, J=7.5 Hz, 4H), 7.10 (d, J=6.0 Hz, 4H), 8.48 (d, J=6.0 Hz, 4H) ppm; 13C NMR (75 MHz, CDCl3) delta 29.4, 29.7, 29.8, 29.9, 30.6, 35.5, 124.0, 149.6, 151.8 ppm.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Crooks, Peter; Dwoskin, Linda P.; Zheng, Guangrong; Sumithran, Sangeetha; US2009/318503; (2009); A1;,
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