Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34883-46-0, name is 1-Iodo-2-phenoxybenzene, A new synthetic method of this compound is introduced below., Product Details of 34883-46-0
[1030] To an ice- cooling mixture of 1-iodo-2-phenoxybenzene (0.404 g, 1.36 mmol) in THF (3 mL) was added isopropylmagnesium bromide (1.36 mL, 1.0 M solution in THF)drop-wise. After stirring at 0C for 1.5 h, a solution of compound 63 (100 mg, 0.27 mmol) in THF (2 mL) was quickly added drop-wise to the mixture above. The resulted mixture was stirred at 0C for 30mm, then slowly warmed up to room temperature and stirred for lh, the reaction mixture was once more cooled down to about 0C, and saturated ammonium chloride solution (5 mL) was added. Then the solvent was evaporated. The aqueous residue thatremained was diluted with water (10 mL), and the mixture was extracted with dichloromethane (10 mL x 3). The combined organic phase was washed with brine and dried over sodium sulfate, filtered and concentrated to afford compound 148.2 (80 mg, yield: 55%)as a yellow solid. [1031] m/z: [M+H]537
The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SHANGHAI DE NOVO PHARMATECH CO.,LTD.; LI, Qun; GAO, Daxin; (158 pag.)WO2016/131380; (2016); A1;,
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