Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35674-27-2, name is 4-Iodo-3-nitrobenzoic acid, A new synthetic method of this compound is introduced below., Formula: C7H4INO4
To an Ar purged solution of 4-iodo-3-nitro-benzoic acid (50.0 mg, 0.171 mmol) in DCM (1.0 mL) added oxalyl chloride (29 muL, 0.341 mmol), followed by DMF (1 drop) at 22 C. After 30 minutes, the conversion to the acid chloride was confirmed by treating a small aliquot of the reaction mixture with MeOH and observing the resulting methyl ester by LC/MS. The reaction was concentrated and DCM (1.0 mL) was added to make a stock solution of the crude acid chloride.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; RenoTarget Therapeutics, Inc.; Wang, Jujun; Tsao, Allen; Liu, Xiaomei; (34 pag.)US2018/127383; (2018); A1;,
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