Reference of 21740-00-1, The chemical industry reduces the impact on the environment during synthesis 21740-00-1, name is 5-Bromo-2-iodobenzoic acid, I believe this compound will play a more active role in future production and life.
A solution of 5-bromo-2-iodobenzoic acid (10.0 g, 30.6 mmol) in DMF was treated with (2.11 g, 30.6 mmol) 1,2,3-triazole, 14.09 g (61.2 mmol) K3PO4.H2O and 583 mg (3.06 mmol) CuI. The mixture was heated at 60 C. for 3 hours with stirring under N2. The reaction was cooled to rt, diluted with water and acidified with 1N HCl. The mixture was partitioned with EtOAc three times. The organic layers were combined, rinsed with brine, dried over MgSO4, filtered and concentrated. The residue was purified by column chromatography (EtOAc in hexanes, 1% AcOH buffer) to give the faster eluting desired 5-bromo-2-(2H-1,2,3-triazol-2-yl)benzoic acid, A-3. Data for A-3: 1HNMR (500 MHz, DMSO-d6) delta 13.4 (br s, 1H), 8.12 (m, 2H), 7.94-7.88 (m, 2H), 7.78-7.73 (m, 1H) ppm. The undesired 5-bromo-2-(1H-1,2,3-triazol-2-yl)benzoic acid eluted second.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2-iodobenzoic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Bergman, Jeffrey M.; Breslin, Michael J.; Coleman, Paul J.; Cox, Christopher D.; Mercer, Swati P.; Roecker, Anthony J.; US2008/132490; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com