Some common heterocyclic compound, 696-41-3, name is 3-Iodobenzaldehyde, molecular formula is C7H5IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3-Iodobenzaldehyde
The mixture of 3-iodobenzaldehyde (1, 4.00 g, 17.2 mmol) in Deoxo-Fluor (12 mL) was stirred at room temperature overnight. Then it was diluted with dichloromethane (150 mL) followed by dropwise addition of 10% aqueous solution of potassium carbonate (200 mL) at 0 C. Phases were separated; organic layer was dried over anhydrous sodium sul- fate, filtered and evaporated. The residue was subjected to flash column chromatog- raphy (Silicagel 60, 0.040-0.063 mm; eluent: cyclohexane) to afford l-(difluoromethyl)- 3-iodobenzene (2) as colorless oil. Yield : 3.22 g (74%). RF (Si02, cyclohexane) : 0.50. *H NMR spectrum (300 MHz, CDCI3, deltaEta) : 7.89-7.85 (m, 1 H); 7.85-7.79 (m, 1 H); 7.52- 7.46 (m, 1 H); 7.24-7.17 (m, 1 H); 6.59 (t, J = 56.2 Hz, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 696-41-3, its application will become more common.
Reference:
Patent; NOVO NORDISK A/S; KRUSE, Thomas; HANSEN, Mikael, Kofoed; MUeNZEL, Martin, Werner, Borchsenius; THØGERSEN, Henning; SAUERBERG, Per; RASMUSSEN, Jakob, Ewald; BEHRENS, Carsten; HØEG-JENSEN, Thomas; BAL?ANEK, Vojtech; DROBNAKOVA, Zuzana; DRO?, Ladislav; HAVRANEK, Miroslav; KOTEK, Vladislav; ?TENGL, Milan; ?NAJDR, Ivan; VANOVA, Hana; (202 pag.)WO2019/92125; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com