Application of 101335-11-9, A common heterocyclic compound, 101335-11-9, name is 2-Chloro-4-fluoro-1-iodobenzene, molecular formula is C6H3ClFI, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a 15 mL reaction tube, ArI (1 mmol), (i-Pr)2NEt (2 mmol),DMF (0.5 mL) and 5 mg of PdCl2/PANI were added. The reactionmixture was stirred at 140 C under air for 2.5 h. After the reaction,the catalyst was isolated by centrifugalization, washed by deionized water and ethanol, vacuum dried at 60 C and then reused in the next round of reaction. Organic phase was collected, add saturatedsalt water (2 mL), extracted with ethyl acetate (15 mL), thenthe organic phase was dried with anhydrous Na2SO4. The productwas separated and purified by silica gel column chromatography(eluent: petroleum ether).
The synthetic route of 101335-11-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liang, Yanping; Liu, Wanyi; Song, Manrong; Sun, Yanyan; Wang, Gang; Wu, Zhiqiang; Zhan, Haijuan; Journal of Catalysis; vol. 384; (2020); p. 177 – 188;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com