Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 101066-87-9, name is 4-Iodo-2-(trifluoromethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Iodo-2-(trifluoromethyl)benzonitrile
A suspension of frans-1-(4-methoxybenzyl)hexahydropyrano [3,4-cfl imidazol-2(3/-/)-one [racemic (±)] (0.25 g, 0.95 mmol), 4-iodo-2-(trifluoromethyl)benzonitrile (0.28 g, 0.95 mmol), frans-A/,A/’-dimethylcyclohexane-1 ,2-diamine (0.032 g, 0.29 mmol) and potassium carbonate (0.395 g, 2.86 mmol) in toluene (15 ml_) was degassed for 30 min in a microwave vial. Cul (0.009 g, 0.05 mmol) was added and the vial was sealed with an aluminum cap. The sealed vial was kept in a preheated oil bath at 1 10 C and stirred for 12 h. The reaction mixture was cooled to RT, filtered through a pad of celite, and filtrates were concentrated under reduced pressure to give a black residue. The residue was purified by column chromatography on silica gel (dichloromethane/methanol = 100:0 to 99: 1 ) to give the title compound (0.17 g, 41.0%) as an off white solid. LCMS: m/z 432.1 [M+H]+; H NMR (400 MHz, CDCI3) delta 7.80-7.74 (m, 2H), 7.54 (d, 1 H), 7.20 (d, 2H), 6.84 (d, 2H), 4.50 (d, 1 H), 4.40-4.30 (m, 2H), 4.15-4.05 (m, 1 H), 3.80 (s, 3H), 3.65 (ddd, 1 H), 3.50-3.20 (m, 2H), 3.10 (ddd, 1 H), 1.90 (d, 1 H), 1 .72-1.68 (m, 1 H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 101066-87-9.
Reference:
Patent; NOVARTIS AG; BOCK, Mark; CHIKKANNA, Dinesh; GERSPACHER, Marc; KHAIRNAR, Vinayak; LAGU, Bharat; PANDIT, Chetan; WO2013/84138; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com