Related Products of 624-75-9,Some common heterocyclic compound, 624-75-9, name is 2-Iodoacetonitrile, molecular formula is C2H2IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a three-necked flask, add 40 g of raw material 2 and 12 g of catalyst 3 (R = 3,5-trifluoromethylbenzyl, R1 = vinyl, R2 = hydrogen) and 1.5 L of chlorobenzene, cool to 0 C with stirring, and add 300 ml 50% aqueous sodium hydroxide solution. Subsequently, 32 g of a solution of iodoacetonitrile (ICH2CN) in 500 ml of chlorobenzene was added. After the addition, the solution was stirred at 0 C until the TLC detection reaction was completed. 40 g of crude product, chiral purity (HPLC) = 72: 28, yield 80%. The crude product was recrystallized from 300 ml of ethyl acetate to obtain 25.0 g of white solid 4 with a yield of 52%, a specific rotation of + 102 (c = 1, chloroform), and a chiral HPLC ?99.92%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodoacetonitrile, its application will become more common.
Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Ruipeng; Zhou Weicheng; Lin Kuaile; Chen Liang; Pan Jing; Zhou Ting; Liu Zhenren; Li Hongyan; (16 pag.)CN110563605; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com