Adding a certain compound to certain chemical reactions, such as: 71838-16-9, name is 2-Bromo-1-iodo-4-methylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 71838-16-9, SDS of cas: 71838-16-9
General procedure: The following were charged to a screw-capculture tube: siloxane 8a (0.101 g, 0.703 mmol, 1.0 equiv), THF (4 mL), 1-iodo-2,5-dimethoxy-4-methylbenzene (9) (0.293 g, 1.05 mmol, 1.5 equiv), and TBAF (1.40 mL 1 M in THF, 1.40 mmol) followed byPd2(dba)3 (0.064 g, 0.070 mmol, 10 mol %). The tube was capped and after stirring 5 min, the tube was placedin a 50 C oil bath for 18 h. The cooled mixture was filtered through a plug of silica gel, rinsing the plug with Et2O. The filtrate was concentrated by rotary evaporation and purified by flash chromatography (2:1hexanes:EtOAc) to provide 10 as a pale yellow oil (0.152 g, 0.643 mmol, 92%).
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Reference:
Article; Vyvyan, James R.; Engles, Courtney A.; Bray, Scott L.; Wold, Erik D.; Porter, Christopher L.; Konev, Mikhail O.; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 2122 – 2127;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com