Reference of 124700-41-0, These common heterocyclic compound, 124700-41-0, name is 2-Fluoro-5-iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Fluoro-5-iodobenzoyl chloride (45f) A suspension of the acid (5.37 g, 20.19 mmol) in SOCl2 (40.82 g, 25 mL, 343 mmol) was refluxed for 22h. The solvents were removed by rotary evaporation and the residue partitioned between EtOAc and saturated aqueous Na2CO3. The organic extracts were dried over MgSO4 and concentrated yielding 45f (5.36 g, 93%) as a pale pink solid which was used in the next step without further purification: 1H NMR (CDCl3) 6.96 (t, J=6.0 Hz, 1H), 7.90-7.94 (m, 1H), 8.35 (d, J=3.0 Hz, 1H).
Statistics shows that 2-Fluoro-5-iodobenzoic acid is playing an increasingly important role. we look forward to future research findings about 124700-41-0.
Reference:
Patent; PFIZER INC; US2005/90529; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com