Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5471-81-8, name is Methyl 4-iodo-3-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C9H9IO2
Under a protective atmosphere of inert gas, Pd(OAc)2 (2.2 mg, 10 mol%), XPhos (19.1 mg, 20 mol%), NBE-CO2K (3.5 mg, were added to a 4.0 mL reaction flask equipped with a magnetic stir bar. 10 mol%), methyl 3-methyl-4-iodobenzoate (0.2 mmol, 1.0 equiv.), (8R, 9S, 13S, 14S)-6,7,8,9,11,12,13,14, 15,16-decahydro-13-methyl-3-(((R)-oxiran-2-yl)methoxy)-17H-cyclopenta[a]phenanthrene-17-one(0.6mmol,3.0 equiv.) and dry N-methylpyrrolidone (1.0 mL). The reaction flask was capped and stirred at room temperature for about 5 minutes.The mixture was then heated to 80 C and stirred for 24 hours. After the reaction vessel was cooled to room temperature, it was quenched with water (10 mL).Extract with butyl ether (3 x 10 mL), dry over Na2SO4, Purified by column chromatography, the eluent was dichloromethane.Yield 7-methyl-2-(((8R,9S,13S,14S)-7,8,9,11,12,13,14,15,16,17-decahydro-13-methyl-17 -oxygenGeneration-6H-cyclopenta[a]phenanthr-3-yl)oxy)methyl)-2,3-dihydrobenzofuran-5-carboxylic acid methyl ester 74mg (colorless oilLiquid, yield 78%).
According to the analysis of related databases, 5471-81-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Wuhan University; Zhou Qianghui; Wu Chenggui; Cheng Honggang; (20 pag.)CN108329285; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com