Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 90347-66-3, name is Methyl 3-iodo-4-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., name: Methyl 3-iodo-4-methylbenzoate
A suspension of Example 191A (2.32 g, 6.62 mmol), methyl 3-iodo-4-methylbenzoate (1.83 g, 6.62 mmol), cesium fluoride (2.01 g, 13.25 mmol) and [(i-butyl)2PCl]2PdCl2 (PXPd, 108 mg, 0.20 mmol) in AyV-dimethylformamide (33 mL) was warmed at 90C for 18 hours. The mixture was cooled and diluted with ethyl acetate and extracted with water (3x) and saturated sodium chloride solution. The solution was dried ( a2S04), filtered, and stirred with 3-(mercaptopropyl) silica gel for 1 hour. Concentration in vacuo afforded a brown oil, which was chromatographed over a 220 g silica gel cartridge, eluting with 10-60% ethyl acetate in hexanes. The solid obtained was triturated with ether-hexanes and collected by filtration. After drying in a vacuum oven at 50 C for 18 hours, these procedures afforded the title compound (1.43 g, 58%>) as white solid. MS (ESI+) m/z (rel abundance) 373 (100, M+H)+, 374 (23).
According to the analysis of related databases, 90347-66-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBOTT LABORATORIES; ABBOTT GMBH & CO.KG; MARING, Clarence J.; PRATT, John K.; CARROLL, William A.; LIU, Dachun; BETEBENNER, David A.; HUTCHINSON, Douglas K.; TUFANO, Michael D.; ROCKWAY, Todd W.; SCHOEN, Uwe; PAHL, Axel; WITTE, Adreas; WO2012/87833; (2012); A1;,
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