Related Products of 444-29-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 444-29-1 as follows.
General procedure: A Schlenk-type flask, equipped with a magnetic stirring bar, was charged under nitrogen with K2CO3 (246 mg, 1.78 mmol) and with a DMF solution (5 mL) of Pd(OAc)2 (5 mg, 0.022 mmol). A DMF solution (5 mL) of the ortho-substituted aryl iodide (0.56 mmol), the 2-bromophenol (0.56 mmol), and norbornene (63 mg, 0.67 mmol) or norbornadiene (123 mg, 1.34 mmol) was then added. The resulting mixture was stirred in an oil bath at 105 °C for 24?66 h. After cooling to room temperature, the mixture was diluted with EtOAc (30 mL) and washed with a saturated solution of NaCl (3×25 mL). The organic layer was dried over anhydrous Na2SO4, the solvent was removed under reduced pressure and the products were isolated by flash column chromatography on silica gel using mixtures of hexane?EtOAc as eluent.
According to the analysis of related databases, 444-29-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Motti, Elena; Della Ca, Nicola; Xu, Di; Armani, Simone; Aresta, Brunella Maria; Catellani, Marta; Tetrahedron; vol. 69; 22; (2013); p. 4421 – 4428;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com