Electric Literature of 25245-27-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a dioxane (2 mL) solution of N-tosylhydrazone (0.24 mmol), tBuOLi (0.53 mmol), Pd2dba3 (0.02 mmol), and XPhos (0.04 mmol) was added the required aryl iodide (0.24 mmol). The mixture was stirred at 90 C for 5 h CH2Cl2 (5 mL) was then added to the cooled mixture which was filtered over a pad of Celite. After concentration, the residue was purified by silica gel chromatography to yield 1a-c, 1k.
The synthetic route of 1-Iodo-3,5-dimethoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Rasolofonjatovo, Evelia; Provot, Olivier; Hamze, Abdallah; Rodrigo, Jordi; Bignon, Jerome; Wdzieczak-Bakala, Joanna; Desravines, Deborah; Dubois, Joelle; Brion, Jean-Daniel; Alami, Mouad; European Journal of Medicinal Chemistry; vol. 52; (2012); p. 22 – 32;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com