These common heterocyclic compound, 58313-23-8, name is Ethyl-3-iodobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 58313-23-8
3-Allyl-benzoic acid ethyl ester (18-7).; A -45 C solution of ethyl 3-iodobenzoate (2.434 g, 8.8 mmol) in 40 mL THF was treated with J-PrMgCl (4.8 mL, 9.6 mmol, 2 M/ether). After 1 h, allyl bromide (1.6 mL, 18.9 mmol) was added followed by CuCN (79 mg, 0.88 mmol). The reaction was stirred for 1 h and then was quenched by addition of 50 mL saturated NH4Cl solution. Water (30 mL).was added and the resulting mixture was extracted with ethyl acetate (3 x 50 mL). The combined ethyl acetate solution was dried (MgSO4), filtered and evaporated. Purification by flash chromatography on silica gel (5% ethyl acetate/hexanes -> 10%) gave the title compound (1.145 g, 68%).
The synthetic route of Ethyl-3-iodobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALLERGAN, INC.; WO2006/63179; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com