Synthetic Route of 628-21-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 628-21-7 as follows.
Example 38: Synthesis of 2-(2,6-Dimethyl-phenyl)-l-oxo-octahydro-isoindole-3a- carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide[0190] a) Lithium bis(trimethylsily)amide (1.0 M in THF, 3.8 mL, 2.4 mmol) was added to a solution of l-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3 -carboxylic acid methyl ester (0.4 g, 1.6 mmol) in THF (16 mL) in a reaction flask at -50 C and stirred for 5 min. The reaction was then warmed to 0 C, and addition of 1,4-diiodobutane (0.79 g, 2.6 mmol) was followed. The reaction was warmed to room temperature and stirred for 1 h. The reaction quenched saturated NH4C1. The layers were separated and the aqueous layer was extracted with EtOAc (3X). The combined organic layers were dried (MgS04) and concentrated under reduced pressure. The residue was purified by flash chromatography (Si02, 0-50% hexanes/EtOAc) to give the desired compound in 63% yield (0.3 g).
According to the analysis of related databases, 628-21-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CHEMOCENTRYX, INC.; CHARVAT, Trevor T.; CHU, Hiufung; KRASINSKI, Antoni; LANGE, Christopher W.; LELETI, Manmohan Reddy; POWERS, Jay P.; PUNNA, Sreenivas; SULLIVAN, Timothy J.; UNGASHE, Solomon; WO2011/35332; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com