In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5326-47-6, name is 2-Amino-5-iodobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5326-47-6
The starting material 2-amino-5-iodo benzoic acid (1) (15mmol, 4 . 0g) is added to 15 ml of anhydrous methanol solution, then added to this solution in 3M the mass fraction of the 70% concentrated sulfuric acid. Heating to reflux 6h, then room temperature stirring 12h. After the completion of reaction, reducing pressure and evaporating solvent, then added to the residues in the bottle 100 ml saturated sodium bicarbonate solution, ethyl acetate (3×30 ml) extraction. Obtaining organic layer, saturated salt water (3×20 ml) washing, layered takes organically phase is dried with anhydrous sodium sulfate. Filtering, by reduced pressure evaporation to dry solvent to obtain 2-amino-5-iodo benzoic acid methyl ester (2) crude 3.96g, yield: 94.5%
The synthetic route of 5326-47-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong University; Liu, Xinyong; Zhan, Peng; Kang, Dongwei; (22 pag.)CN105669653; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com