Electric Literature of 640280-28-0, The chemical industry reduces the impact on the environment during synthesis 640280-28-0, name is 1-Bromo-2-iodo-4-(trifluoromethyl)benzene, I believe this compound will play a more active role in future production and life.
Example 36: 5-(2-(l,2,3,6-Tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-N-(thiazol-2- yl)-3 ,4-dihydroisoquinoline-2( 1 H)-sulfonamide hydrochloride Step 1 : tert-Butyl 4-(2-(isoquinolin-5-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine- 1 (2H)-carboxylate A solution of Ci2Pd(dppf)-CH2Ci2 adduct (Strem Chemicals Inc., Newburyport, MA, 1.157 g, 1.416 mmol), (n-tert-butoxycarbonyl)-l,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester (8.76 ml, 28.3 mmol), l-bromo-2-iodo-4-(trifluoromethyl)benzene (9.94 g, 28.3 mmol), and potassium phosphate (36.1 g, 170 mmol) in 100 mL dioxane, 40 mL water was heated to 100 C 3 hours. LC/MS showed complete consumption of starting material. Isoquinolin-5 -ylboronic acid (4.90 g, 28.3 mmol) and Ci2Pd(AmPhos) (Sigma-Aldrich, St. Louis, MO, 1.003 g, 1.416 mmol) were added, and the reaction mixture was again heated to 100 C for an additional hour. The reaction mixture was allowed to cool to room temperature and was diluted with diethyl ether. The organics were washed with water, then brine, dried over MgS04 and concentrated. Purification of the resulting residue by si81ica gel column chromatography (0 to 100% EtO Ac/heptane) gave tert-butyl 4-(2-(isoquinolin-5-yl)-5- (trifluoromethyl)phenyl)-5,6-dihydropyridine-l(2H)-carboxylate (9.80 g, 21.56 mmol).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-iodo-4-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AMGEN INC.; DINEEN, Thomas; KREIMAN, Charles; WEISS, Matthew; GEUNS-MEYER, Stephanie; WO2013/134518; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com