Synthetic Route of 25309-64-2,Some common heterocyclic compound, 25309-64-2, name is 1-Ethyl-4-iodobenzene, molecular formula is C8H9I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 2 (120mg, 0.37mmol) was dissolved in DMF (0.8mL, 0.47mol / L), was added Et3N (0.14mL, 1.11mmol), 1- ethyl-4-iodo-benzene (97.2mg, 0.42mmol), stir, add Pd (OAc)2(3.71mg, 0.017mmol), gradually warmed to 80 , heated to reflux for 8h, the reaction was monitored by TLC, After completion of the reaction, the reaction solution was cooled to room temperature.Addition of distilled water (20mL), and extracted with anhydrous diethyl ether (20mL × 5), and the organic layer was washed with Na2SO4Drying, rotary evaporation, purified by silica gel column to give product 3E (78% yield) and 4E (yield 12%).
The synthetic route of 25309-64-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tianjin Shang De Yaoyuan Technology Co., Ltd.; Nankai University; Chen Yue; Zhang Quan; Fan Hongxia; Ding Yahui; Long Jing; (16 pag.)CN104211669; (2018); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com