Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77317-55-6, name is Methyl 2-amino-5-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Methyl 2-amino-5-iodobenzoate
EXAMPLE 1002-(4-((2-Chlorothiophene-5-carboxamido)methyl)-lH-l,2,3-triazol-l-yl)-5-(2-oxopyridin- l(2H)-yl)benzoic acid (100); SCHEME 9Step 1 : Methyl 2-amino-5-iodonezoate (3.00 g, 10.8 mmol) was stirred in 35 rnL TFA in ice bath. To it was added sodium nitrite (820 mg, 12 mmol) in small portions. The mixture was stirred in ice bath for 40 min. To it was added an ice-cold solution of sodium azide (1.41 g, 21.6 mmol) in 8 mL water. The mixture was stirred for 3 hrs, diluted with ethyl acetate (500 mL), washed with brine three times, dried, and concentrated in vacuo to give compound 9.2 in quantitative yield.
According to the analysis of related databases, 77317-55-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; SCARBOROUGH, Carroll; WO2008/86226; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com