Reference of 450412-29-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 450412-29-0, name is 1-Bromo-3-fluoro-2-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
200 g (664 mmol) of 1-bromo-3-fluoro-2-iodobenzene,101 g (664 mmol) of 2-methoxyphenylboronic acid and 137.5 g (997 mmol) of sodium tetraborate were dissolved in 1000 ml of THF and 600 ml of water and degassed.9.3 g (13.3 mmol) of bis (triphenylphosphine) palladium (II) dichloride and 1 g (20 mmol) of hydrazine hydroxide were added.The reaction mixture was stirred at 70 C for 48 hours under a protective atmosphere.Toluene was added to the cooled solution,Wash repeatedly with water, dry and concentrate.The product was purified by silica gel column chromatography with toluene / heptane (1: 2). Yield: 155 g (553 mmol),Theoretical yield 83%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-fluoro-2-iodobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK PATENT GMBH; PARHAM, AMIR HOSSAIN; LUDEMANN, AURELIE; JOOSTEN, DOMINIK; GROSSMANN, TOBIAS; KROEBER, JONAS VALENTIN; (90 pag.)TW2017/31839; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com