Related Products of 112671-42-8, These common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under anaerobic conditions, In 1 liter single-necked flask was charged with 100 g of compound 7, 2-thiophene boronic acid pinacol ester, 64g, Na2CO3 (20g, 184 mmol) in tetrahydrofuran (500 mL), and deionized water (50 mL), catalyst Pd (PPh3) 4 (5 g, 4.3 mmol). The mixture was stirred at 90 C for 3 days and night. The organic compound was added with 3 liters of deionized water and extracted three times with CH2Cl2 (3 X 1000 mL). The extract was dried with anhydrous Na2SO4 for four hours and the solvent was evaporated with a rotary evaporator. The residue was separated by 300 mesh analytical silica gel column and eluted with CH2Cl2 / n-hexane (1: 10). The effluent was evaporated to dryness to give the product 8 as a yellow oily liquid (63 g,)
The synthetic route of 112671-42-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Henan Normal University; Qin Ruiping; Jiang Yurong; Zhang Kaixuan; Zhang Haoxing; Zhang Qunying; (7 pag.)CN104098591; (2017); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com