Adding a certain compound to certain chemical reactions, such as: 627-31-6, name is 1,3-Diiodopropane(stabilized with Copper chip), belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-31-6, Computed Properties of C3H6I2
To a solution of ethyl 2-(4-nitrophenyl)acetate (9.0 g, 43 mmol) in DMF (100 mL) was added NaH (3.6 g, 90 mmol, 60% in oil) at 0 C. Then the reaction mixture was allowed to warm to RT and stirred for 15 min. The mixture was cooled to 0 C again and 1,3- diiodopropane (10 mL, 89 mmol) was added. The resulting mixture was stirred at 0 C for 30 min, then warmed to RT and stirred at RT for 1 h. The reaction was diluted with NH4C1 (sat., 200 mL), extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2S04i filtered and concentrated in vacuo to afford a residue, which was purified by column chromatography on silica gel (EtOAc in petroleum ether: 0 – 5% gradient) to give the title compound (I-D). lH NMR (400 MHz, CDC13) delta 8.23 – 8.12 (m, 2 H), 7.52 – 7.38 (m, 2 H), 4.18 – 4.04 (m, 2 H), 2.94 – 2.82 (m, 2 H), 2.57 – 2.45 (m, 2 H), 2.18- 2.04(m, 1 H), 2.00- 1.75 (m, 1H), 1.22 – 1.12 (m, 3 H).
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Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHOU, Hua; ACHAB, Abdelghani; FRADERA, Xavier; HAN, Yongxin; LI, Derun; MCGOWAN, Meredeth, A.; SCIAMMETTA, Nunzio; SLOMAN, David, L.; YU, Wensheng; (98 pag.)WO2019/27855; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com