Application of 1643-29-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1643-29-4, name is 3-(4-Iodophenyl)propanoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 3-(p-iodophenyl)propanoic acid (63 mg, 0.22 mmol) and EDC.HC1 (57 mg, 0.30 mmol) in CH2C12 (5 mE) was added NEt3 (84 pL, 0.60 mmol) and the reaction was stirred at it under Ar for 30 mm. Then a solution of EuO.3OtBu (2) (103 mg, 0.22 mmol) in CH2C12 (1 mE) was added and the reaction was stirred overnight at it under Ar. The reaction was diluted with 10 mE CH2C12 and washed successively with H20 and saturated NaC1 solution. The organic layer was dried over MgSO4, filtered and concentrated under reduced pressure to give the crude product as a pale oil. The crude product was purified by flash chromatography (100% hexane to 100% EtOAc over 20 mm), and EuO-IPPA.3OtBu (6) was isolated as a clear oil (87 mg; 53%). ?H NMR (500 MHz, CDC13) oe 7.57 (d, 2H, J=8.2 Hz), 6.96 (d, 2H, J=8.2 Hz), 6.61 (br s, 1H), 5.61 (d, 1H, J=8.2 Hz), 5.44 (d, 1H, J=7.8 Hz), 4.34 (m, 1H), 4.23 (m, 1H), 3.29-3.16 (m, 2H), 2.90 (t, 2H, J=7.8 Hz), 2.46 (t, 2H, J=7.8 Hz), 2.27 (m, 2H), 2.09 (m, 1H), 1.85 (m, 1H),1.73 (m, 1H), 1.58-1.40 (m, 3H), 1.46 (s, 9H), 1.42 (s, 18H). ESI(+)=732.4 [M+H]. Calculated mass: 731.3
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Iodophenyl)propanoic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Cornell University; Babich, John W.; Kelly, James M.; Amor-Coarasa, Alejandro; Ponnala, Shashikanth; (36 pag.)US2017/368005; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com