Synthetic Route of 6828-35-9, These common heterocyclic compound, 6828-35-9, name is 5-Chloro-2-iodoaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of 2-iodoaniline (0.5 mmol) and benzaldehyde (0.6mmol) in dry DMSO (1.5 mL), selenium powder (1.5 mmol), catalyst(0.05 mmol), and KOH (1.0 mmol) were added, the reactionmixture was stirred in a sealed tube under argon atmosphere at 120 C for 36 h. After the reaction was finished,the mixture was cooled to r.t., diluted with sat. aq NH4Cl (15mL), and extracted with EtOAc (3 × 10 mL). The organic layerwas dried over Na2SO4, and the solvent was removed underreduced pressure. The residue was purified by silica gel columnchromatography to afford the corresponding product 3aa.
Statistics shows that 5-Chloro-2-iodoaniline is playing an increasingly important role. we look forward to future research findings about 6828-35-9.
Reference:
Article; Su, Tao; Xie, Shishun; Li, Bifu; Yan, Jun; Huang, Ling; Li, Xingshu; Synlett; vol. 26; 2; (2015); p. 215 – 220;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com