175278-30-5, name is 4-Bromo-2-ethyl-1-iodobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 175278-30-5
20 g (64.3 mmol) of 1-iodo-2-ethyl-4-bromobenzene and 12 g (64.3 mmol) of 4-n-hexylphenylacetylene are initially introduced into 300 ml of triethylamine and 250 mg (1.3 mmol) Of copper (I) iodide and 900 mg (1.3 mmol) of bis (triphenylphosphine) palladium (II) chloride are added and the mixture is stirred at RT for 3 h and then refluxed for 1 h.Cool the batch, add water and heptane, and separate the phases. The organic phase is washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and evaporated in a rotary evaporator. The residue is purified by column chromatography (SiO 2, heptane); the product is obtained as a colorless oil.
The synthetic route of 175278-30-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; JASPER, CHRISTIAN; MONTENEGRO, ELVIRA; PAULUTH, DETLEF; REIFFENRATH, VOLKER; MANABE, ATSUTAKA; (43 pag.)JP6218607; (2017); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com