Reference of 101066-87-9, These common heterocyclic compound, 101066-87-9, name is 4-Iodo-2-(trifluoromethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of 4c (6.0 g, 24.7 mmol), 4-iodo-2-(trifluoromethyl)benzonitrile (8.42 g, 28.4 mmol), Xantphos (2.14 g, 3.70 mmol),Pd2(dba)3 (1.13 g, 1.23 mmol) and Cs2CO3 (12.05 g, 36.98 mmol)in toluene (70 ml) was stirred at 80 C for 18 h, and the resultingmixture was partitioned between water and ethylacetate. Theorganic layer was dried over MgSO4, and concentrated in vacuo.The residue was purified by silica gel column chromatography(n-hexane:EtOAc = 50:1 to 1:2) to afford 4-((2S,3S)-3-{[tert-Butyl(dimethyl)silyl]oxy}-2-ethyl-5-oxopyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile
The synthetic route of 101066-87-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Aikawa, Katsuji; Asano, Moriteru; Ono, Koji; Habuka, Noriyuki; Yano, Jason; Wilson, Keith; Fujita, Hisashi; Kandori, Hitoshi; Hara, Takahito; Morimoto, Megumi; Santou, Takashi; Yamaoka, Masuo; Nakayama, Masaharu; Hasuoka, Atsushi; Bioorganic and Medicinal Chemistry; vol. 25; 13; (2017); p. 3330 – 3349;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com