Application of 41860-64-4,Some common heterocyclic compound, 41860-64-4, name is 4-Fluoro-2-iodo-1-nitrobenzene, molecular formula is C6H3FINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A. 5-Fluoro-4′-Methylsulfinyl-2-Nitrobiphenyl sulfide 4-Methylsulfinylthiophenol (0.2 mole) is dissolved in dry tetrahydrofuran (100 ml.) and sodium hydride (50% dispersion in mineral oil, 0.2 mole) is added over 30 minutes. The solution is evaporated to dryness and the residue is rinsed well with n-hexane. The powdered salt is stirred under N2 at reflux with 4-fluoro-2-iodonitrobenzene (0.2 mole) in dry dimethylformamide for 16 hours, evaporated to dryness and extracted into chloroform (3 times 200 ml.). The organics are washed with water (2*100 ml.), separated and dried (MgSO4). The solution is filtered, evaporated to dryness and put on a column of silica-gel (Baker 2 in. times 2 ft.) and various fractions are eluted with portions of benzene-n-hexane. In this way, pure 5-fluoro-4′-methylsulfinyl-2-nitrobiphenyl sulfide is obtained.
The synthetic route of 41860-64-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Cell Pathways, Inc.; US6020379; (2000); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com