Adding a certain compound to certain chemical reactions, such as: 628-77-3, name is 1,5-Diiodopentane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 628-77-3, Product Details of 628-77-3
(S) – (4-hydroxy-5-methoxy-2-nitrophenyl) (2- (hydroxymethyl) -4-methylenepyrrolidin-1-yl) methanone (0.801 g, 2.60 mmol) in butanone (10 ml) was added Cs 2CO 3, (2.50 g, 7.67 mmol) , followed by addition of 1, 5-diiodopentane (415 mmol, 1.28 mmol) . The mixture was stirred for 26 h, concentrated and purified on SiO 2 column eluted with MeOH/CH 2Cl 2 (1: 15 to 1: 5) to afford the title compound (0.675 g, 77%yield, 95%pure) . MS ESI m/z calcd for C 33H 41N 4O 12 [M+H] + 685.26, found 685.60.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,5-Diiodopentane, and friends who are interested can also refer to it.
Reference:
Patent; HANGZHOU DAC BIOTECH CO., LTD; ZHAO, Robert Yongxin; ZHUO, Xiaotao; YANG, Qingliang; ZHAO, Linyao; HUANG, Yuanyuan; YE, Hangbo; YANG, Chengyu; LEI, Jun; GAI, Shun; GUO, Huihui; JIA, Junxiang; BAI, Lu; XIE, Hongsheng; ZHOU, Xiaomai; GUO, Zhixiang; LI, Wenjun; CAO, Mingjun; ZHENG, Jun; YE, Zhichang; YANG, Yanlei; (325 pag.)WO2020/6722; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com