Synthetic Route of 181765-86-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 181765-86-6 as follows.
A. 5-Bromo-2-(trifluoromethyl)benzoate. To a solution of methyl 5- bromo-2-iodobenzoate (4.65 g, 13.64 mmol) and methyl 2,2-difluoro-2- (fluorosulfonyl)acetate (2.6 mL, 20.44 mmol) in N-methyl-2-pyrrolidinone (10 mL) was added copper(I) bromide (235 mg, 1.638 mmol). The reaction mixture was stirred at 120C for 15 h in a sealed tube. The reaction was partitioned between ethyl acetate and aqueous sodium chloride. The aqueous layer was extracted with ethyl acetate (3 x 25 mL), and the organic layers were combined and dried over magnesium sulfate. After filtration, the solvent was removed in vacuo. The residue was purified by silica gel chromatography (1-5% ethyl acetate in hexanes) to give the title compound as an oil (2.9 g, 10.25 mmol, 75% yield); 1H NMR (400 MHz, DMSOd6) delta 8.08 (s, IH), 8.01 (d, J= 8.20 Hz, IH), 7.83 (d, J= 8.20 Hz, IH), 3.90 (s, 3H).
According to the analysis of related databases, 181765-86-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2009/89042; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com