Adding a certain compound to certain chemical reactions, such as: 628-77-3, name is 1,5-Diiodopentane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 628-77-3, COA of Formula: C5H10I2
16.1: Methyl (R)-3-tert-butoxycarbonylamino-2-piperidin-1-ylpropanoate 3.1 ml (20.6 mmol) of 1,5-diiodopentane are added to a solution of 5.0 g (19.6 mmol) of commercial methyl (R)-2-amino-3-tert-butoxycarbonylaminopropanoate hydrochloride and 0.22 g (0.6 mmol) of tetrabutylammonium chloride in 50 ml of N,N-diisopropylethylamine. The reaction medium is heated at 127 C. for 5 h and then at 100 C. for 18 h. After evaporation of a maximum amount of N,N diisopropylethylamine, the reaction medium is hydrolyzed and then diluted with ethyl acetate. The organic phase is washed with water, dried over magnesium sulfate, filtered and concentrated under vacuum. The residue obtained is purified by chromatography on silica gel, elution being carried out with a 70/30 heptane/ethyl acetate mixture. 3.7 g (66%) of methyl (R)-3-tert-butoxycarbonylamino-2-piperidin-1-yl-propanoate are obtained in the form of a light oil.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; Clary, Laurence; Chambon, Sandrine; Chantalat, Laurent; Mauvais, Pascale; Roye, Olivier; Schuppli, Marlene; US2012/116072; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com