Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627-31-6, name is 1,3-Diiodopropane(stabilized with Copper chip), A new synthetic method of this compound is introduced below., Safety of 1,3-Diiodopropane(stabilized with Copper chip)
To a solution of ethyl 2-(4-nitrophenyl)acetate (9 g, 43 mmol) in DMF (100 mL) was added NaH (3.6 g, 90 mmol) (60% in oil) at 0 C. The reaction mixture was allowed to warm to RT and was stirred for 15 min. The mixture was cooled to 0 C and 1,3-diiodopropane (10 mL, 89 mmol) was added. The resulting mixture was stirred at 0 C for 30 min, then warmed to RT. After 1 h the reaction mixture was diluted with aqueous NH4C1 (200 mL), and was extracted with EtOAc (200 mLx3). The combined organics were washed with brine (1000 mL), dried over saturated Na2SC>4, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography (SiC , petroleum ether/ EtOAc =50: 1 to 40: 1) to afford ethyl 1-(4-nitrophenyl)cyclobutanecarboxylate.
The synthetic route of 627-31-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MCGOWAN, Meredeth Ann; ACHAB, Abdelghani; FRADERA, Xavier; HAN, Yongxin; LI, Derun; LIM, Jongwon; LIU, Kun; SCIAMMETTA, Nunzio; WHITE, Catherine, M.; YU, Wensheng; ZHANG, Hongjun; ZHOU, Hua; (109 pag.)WO2019/74747; (2019); A1;,
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