These common heterocyclic compound, 63131-30-6, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 63131-30-6
To a solution of compound 56A (3 1.5 g, 99.02 mmol) in EtOH (300 mL)was added NH40Ac (20 g, 259.46 mmol), then the mixture was stirred at 85 oc for 18h. Thereaction mixture was concentrated to remove solvent, then diluted with water (150 mL) andextracted with EA (100 mL x 3), the organic layers were washed with saturated NaHC03(100 mL x 2), dried over Na2S04, filtered and concentrated to give a residue. The residuewas purified by ±lash silica gel chromatography (lSCO.); 220 g SepaFlasM<) Silica FlashColumn, Eluent ofO~lO% Ethyl acetate/Petroleum ethergradient 100 mL/min). Compound56B (26 g, yield: 71.5%) as light yellow solid was obtained. 1H NMR (400MHz, DMSO-d6)8 7.86-7.75 (m, 2H), 7.44- 7.34 (m, 2H), 4.77 (s, lH), 4.05 (q, J= 7.1 Hz, 2H), 1.19 (t, J=7.2 Hz, 3H). MS (ESI) m/z (M--I-i)+317.9.
The synthetic route of Ethyl 3-(4-iodophenyl)-3-oxopropanoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad Owen; YUAN, Shendong; EMAYAN, Kumaraswamy; ADLER, Marc; IBRAHIM, Prabha; (247 pag.)WO2019/190885; (2019); A1;,
Iodide – Wikipedia,
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