Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 387-48-4, name is 3-Fluoro-2-iodobenzoic acid, A new synthetic method of this compound is introduced below., SDS of cas: 387-48-4
Step B: Preparation of Ethyl 2-(3-fluoro-2-iodophcnyl)acctate; 109081 A solution of 3-fluoro-2-iodobenzoic acid ( 14.90 g, 56.0 mmol) was stirred in thionyl chloride ( 150 mL) for 1 hour at reflux. The mixture was cooled to room temperature, and the excess thionyl chloride was removed in vacuo to give the corresponding acid chloride. HbO (20 ml.) was added, and a solution of TMSCHN? (2.0M in Ht2O. I I O mL. 220 mmol) was added. The mixture was stirred for 4 hours, and the excess reagent was quenched by the addition of AcOH. The mixture was then partitioned between EtOAc (200 mL) and saturated NaHCO3 solution. The layers were separated, and the organic layer was washed twice with saturated NaHCO3, once with water, and once with brine once. The organic layer was then dried over anhydrous MgStheta4 and concentrated in vacuo. This material was dissolved in HtOH (200 proof) and silver(I)oxide (2.60 g, 1 1 .2 mmol) was added. The suspension was heated to 800C for 30 minutes, cooled to room temperature, and filtered through celite. The filtrate was concentrated in vacuo, and the resulting oil was purified by flash chromatography to give 9.90 g of product as a yellow oil.
The synthetic route of 387-48-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; WO2008/76427; (2008); A2;,
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