In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 153898-63-6, name is 2-Iodo-5-methoxyaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-Iodo-5-methoxyaniline
The intermediate 3- (3-isopropyl-4-methoxybenzylamino) -1- (3,4,5-trimethoxyphenyl) acetone-2-ynyl (3) (0.20g, 0.52mmol ), 2-iodo-5-methoxyaniline (4) (0.16g, 0.62mmol) was dissolved in dry methanol and a mixture of anhydrous DMSO (1.5), an argon atmosphere, was stirred at 120 60h.After the reaction, by column chromatography (Pe / EtOAc = 7:1) to give a yellow solid intermediate.This intermediate was dissolved in dry of DMF, palladium acetate (11.6mg, 0.052mmol), triethylamine (0.21g, 2.08mmol), stirred for an argon atmosphere 120 14h.After the reaction, by column chromatography (Pe / EtOAc = 5:1) to give a yellow solid, a 2- (4′-methoxy-3′-isopropoxy-phenyl) -3- (3 “, 4”, 5 ‘- trimethoxy-benzoyl) -6-methoxy-indole (5) (131.4mg, the yield 50%).. 1HNMR (500 MHz, CDCl33)delta8.61(s1H)7.93(dJ9.3Hz1H)6.99(s3H)6.91(ddJ4.72.4Hz2H)6.75(ddJ5.03.1Hz2H)4.17(dtJ12.26.1Hz1H)3.86(s3H)3.79(s6H)3.67(s6H)1.20(dJ6.1Hz6H).13C NMR(126MHzCDCl3)delta191.9157.5152.7151.2147.4142.4141.4136.5134.7125.0123.4122.6121.1117.5112.9111.8107.594.771.960.956.155.929.822.1.ESI-MS[M+H]+506.2[M+Na]+528.4.HRMS(ESI)m/z calcd for C29H31NO7[M+H]+506.2173found506.2158
The synthetic route of 153898-63-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong YizhengdaMedical Technology Co Ltd; Sun, Qing; Zhang, Weidong; (13 pag.)CN104262229; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com