In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 181765-86-6
Add compound 7 (9.99 g, 29.4 mmol) to a 250 ml three-necked flaskAnd p-methoxyphenylboronic acid (5.36g, 35.28mmol),Then add 50ml of tetrahydrofuran and 50ml of water and stir,Add bistriphenylphosphonium palladium dichloride (1.03g, 1.47mmol) under a nitrogen atmosphere.When the temperature reached 60 C, sodium carbonate (6.23g, 58.8mmol) was added, and the reaction was refluxed for 12h.Cooled to room temperature, diluted with ethyl acetate, washed with saturated brine, and dried over anhydrous magnesium sulfate,After filtration, the solution was concentrated under reduced pressure and separated by column chromatography to obtain 7.53 g.Compound 8 was a white solid with a yield of 80%.
The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dalian University of Technology; Wang Shisheng; Li Guangzhe; Liu Liqiang; Zhao Weijie; Guo Xiuhan; Li Yueqing; Wang Xu; Dong Huijuan; (21 pag.)CN110041200; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com