Application of 4387-36-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4387-36-4, name is 2-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Weigh 0.6 mM halogenated aromatic hydrocarbon in a reaction flask, add 4 mL of solvent, and fill the reaction flask with nitrogen.Deoxygenation was performed for 30 minutes and 150 muL of triethylamine and 24 mM pyrrole or its derivatives were sequentially added during the deoxygenation. After that, the reaction vessel was sealed, placed over a light-emitting diode (LED) having a wavelength of 450 nm and a power of 30 W to be irradiated, and the reaction was stirred at room temperature for 20 hours.After the end of the reaction, the light source was switched off and the reaction mixture was spin-dried. Column chromatography was performed using petroleum ether and ethyl acetate as eluents. After vacuum drying at 35° C., the carbon-carbon coupling product 6a was obtained. The nuclear magnetic resonance spectrum of compound 6a was obtained. As shown in FIG. 34 and FIG. 35 , the nuclear magnetic carbon spectrum shows that the yield of compound 6a is 96percent, as shown in Table 1. The halogenated aromatic hydrocarbon is o-iodobenzeneacetonitrile and the solvent is acetonitrile.When the pyrrole in Example 16 was replaced with N-methylpyrrole, a carbon-carbon coupling product 6b was obtained. The nuclear magnetic and nuclear magnetic carbon spectra of compound 6b were as shown in FIGS. 36 and 37, and the yield of compound 6b was 96percent, as shown in Table 1. When the pyrrole in Example 16 is replaced with N-phenylpyrrole, a carbon-carbon coupling product 6c is obtained. The nuclear magnetic and nuclear magnetic carbon spectra of compound 6c are shown in Figs. 38 and 39, and the yield of compound 6c is: 58percent, as shown in Table 1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shaanxi Normal University; Fang Yu; Miao Rong; (29 pag.)CN108002991; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com