14452-30-3, name is 1-(3-Iodophenyl)ethanone, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C8H7IO
General procedure: Aryl halide (1.1 eq.), Au complex 1 (1.0 eq.) and a palladium catalyst (10 mol%) was dissolved in THF under nitrogen. The mixture was refluxed until the starting Au-complex was consumed (monitored by TLC). The reaction mixture was concentrated under reduced pressure. The residue was separated and purified by chromatography, to afford the corresponding cross-coupling product.
The synthetic route of 14452-30-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tanimoto, Ryu; Suzuki, Shuichi; Kozaki, Masatoshi; Okada, Keiji; Chemistry Letters; vol. 43; 5; (2014); p. 678 – 680;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com