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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 847685-01-2, name is 4,5-Difluoro-2-iodoaniline, A new synthetic method of this compound is introduced below., Quality Control of 4,5-Difluoro-2-iodoaniline

4,5-Difluoro-2-iodoaniline (Intermediate 27, 1.24 g, 4.86 mmol) was dissolved in anhydrous DMF (15 mL). Pyruvic acid (1.32 g, 15 mmol) and DABCO (1.68 g, 15 mmol) were added and the mixture degassed by alternate vacuum and nitrogen purge. Palladium EPO acetate (56 mg) was then added and the mixture heated to 1000C. for 2h. After cooling to ambient temperature the reaction mixture was filtered through celite, diluted with ethyl acetate (10OmL), washed with 2M HCl (2x 2OmL) and water (2x 2OmL), dried (MgSO4) and evaporated to give the title compound as a dark solid (860 mg, 90%). 1H NMR delta: 7.0 (s, IH), 7.3 (dd, IH), 7.6 (dd, IH), 11.9 (s, IH); MS m/z 196 (m-H)

The synthetic route of 847685-01-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/82400; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com