Synthetic Route of 7681-82-5, These common heterocyclic compound, 7681-82-5, name is Sodium iodide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of 49; A Schlenk tube was charged with complex 3 (83.4 mg, 0.18 mmol), Nal (539.6 mg,3.6 mmol), and 5 mL of THF. The reaction mixture was stirred at room temperature for 8 h. All volatiles were removed under vacuum. The residue was dissolved in toluene, and the resulting suspension was passed through a plug of Celite. All the volatiles were removed, and the residue was washed with diethyl ether (3 x 5 mL) to give 49 as a dark red powder. Yield: 68% (78.5 mg, 0.12 mmol).1H NMR (CD2C12, 300 MHz): delta 7.19 (s, 2H,CHiinid), 5.69 (d, J = 5.91 Hz, 2H, CHpCym), 5.52 (septet, J = 6.60 Hz, 2H, CHiSoP imid), 5.15 (d, J = 5.88 Hz, 2H, CHpcym), 3.29 (septet, J = 6.93 Hz, 1H, CHjsop pcym ), 2.01 (s, 3H, CH3pcym), 1.44 (br, 12H, CH3isop imid), 1.32 (d,13C {1H} NMR (CD2C12, 100MHz): delta 167.6 (C-Ru), 120.1 (CHimid), 108.4 (Cqpcym), 99.8( qpcym), 87.3 (CHpcym), 82.3 (CHpcym), 55.0 (CHjsop jmid), 32.0 (CHjSop pcym), 25.7 (CH3jsop imid), 25.1 (CH3jsop imid), 23.2 (CH3isop pcym), 19.8 (CH3pcym).Anal, calcd for C20H32C12I2N2-Ru (49-3CH2Cl2, 726.3): C, 33.08; H, 4.44; N, 3.86. Found: C, 33.46; H, 4.01; N, 4.03.
The synthetic route of 7681-82-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NANYANG TECHNOLOGICAL UNIVERSITY; HONG, Soon Hyeok; GHOSH, Subhash Chandra; ZHANG, Yao; MUTHAIAH, Senthilkumar; CHEN, Cheng; XU, Xiangya; WO2011/34506; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com